The COPE 15-Session TEEN Healthy Lifestyles Instructor-led program is based on cognitive behavioral therapy, with an emphasis on skills-building to help teens (12-18) manage anxiety, stress, and depression as well as improve healthy behaviors (e.g., physical activity and healthy eating). The 15 weekly sessions are intended to be delivered one on one, in a classroom or via telehealth.  Facilitator-delivered COPE sessions focus on skills, such as recognizing negative thought patterns and changing them, building self-esteem, problem-solving, effective communication, and developing coping tools to effectively manage stress, depression and anxiety. The 15-session program includes PowerPoint presentations for classroom delivery, a parent letter explaining the program and parent newsletters that inform parents of content and skills building that are being taught in the program. The COPE TEEN program is promoted as an adolescent obesity control program with the highest dissemination capability by the National Institutes of Health (see https://ebccp.cancercontrol.cancer.gov/programDetails.do?programId=22686590. 3 COPE TEEN manuals and an instructor guide are included.